Xiaoxu Chen

　　 　　

Xiaoxu Chen, Associated Professor

E-mail:chenxiaoxu1992@outlook.com

Address:College of Animal Science and Technology, Northwest A&F University, Yanling, China, 712100

Education and Working

2023.11 – present  Associated Professor in College of Animal Science and Technology, Northwest A&F University

2020.7 – 2023.7  Postdoctoral Fellow- State Key Laboratory of Reproductive Medicine, Nanjing Medical. University2014.9 – 2020.6  Ph.D,College  of Animal Science and Technology, Northwest A&F University

2010.6 -2014.6.B.Sc., College of Animal Science and Technology, Northwest A&F University

Research Interests

(1) Development, optimization and application of mitochondrial DNA editing technology.

(2) Function of mitochondrial in regulation of spermatogenesis.

(3) The role and function of sperm derived epigenetic factors.

Publications

(1) Chen X#, Chen M#, Zhu Y#, Sun H#, Wang Y#, Xie Y, Ji L, Wang C, Hu Z, Guo X, Xu Z, Zhang J, Yang S, Liang D, Shen B. Correction of a homoplasmic mitochondrial tRNA mutation in patient-derived iPSCs via a mitochondrial base editor. Commun Biol. 2023 Nov 3;6(1):1116.

(2)Chen X#, Liang D#, Guo J#, Zhang J#, Sun H#, Zhang X, Jin J, Dai Y, Bao Q, Wang J, Qian X, Tan L, Hu P, Ling X*, Shen B*, Xu Z*.

DdCBE-mediated mitochondrial base editing in human 3PN embryos.

Cell Discov. 2022, Feb 1; 8(1):8.

(3) Guo J#, Chen X#, Liu Z#, Sun H#, Zhou Y, Dai Y, Ma Y, He L, Qian X, Wang J, Zhang J, Zhu Y, Zhang J*, Shen B*, Zhou F*. DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome. Mol Ther Nucleic Acids. 2021, Mar 8; 27, 73-80.

(4) Qi X#, Chen X#, Guo J#, Zhang X#, Sun H#, Wang J, Qian X, Li B, Tan L, Yu L, Chen W, Zhang L, Ma Y*, Shen B*. Precision modeling of mitochondrial disease in rats via DdCBE-mediated mtDNA editing. Cell Discov. 2021 Oct 19;7(1):95.

(5) Guo J#, Zhang X#, Chen X#, Sun H#, Dai Y#, Wang J, Qian X, Tan L, Lou X*, Shen B*. Precision modeling of mitochondrial diseases in zebrafish via DdCBE-mediated mtDNA base editing. Cell Discov. 2021 Sep 3;7(1):78.

(6) Liu Z#, Chen X#, Zhang P#, Li F, Zhang L, Li X, Huang T, Zheng Y, Yu T, Zhang T, Zeng W*, Lu H*, Lv Y*. Transcriptome-wide Dynamics of m6A mRNA Methylation During Porcine Spermatogenesis. Genomics Proteomics Bioinformatics. 2021 Sep 17: S1672-0229(21)00181-9.

(7)Chen X#, Sun Q#, Zheng Y, Liu Z, Meng X*, Zeng W*, Lu H*. Human sperm tsRNA as potential biomarker and therapy target for male fertility. Reproduction. 2021 Feb;161(2):111-122.

(8) Chen X#, Zheng Y#*, Lei A#, Zhang H, Niu H, Li X, Zhang P, Liao M, Lv Y, Zhu Z, Pan C, Dong W, Chen H, Wu D, Liu W, Hamer G, Zeng S*, Zeng W*. Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG-derived small RNAs present in mature spermatozoa. J Biol Chem. 2020 Aug 7;295(32):10885-10900.

(9)Chen X, Zheng Y, Li X, Gao Q, Feng T, Zhang P, Liao M, Tian X, Lu H*, Zeng W*. Profiling of miRNAs in porcine Sertoli cells. J Anim Sci Biotechnol. 2020 Aug 17; 11: 85.

(10)Chen X, Che D, Zhang P, Li X, Yuan Q, Liu T, Guo J, Feng T, Wu L, Liao M, He Z, Zeng W*. Profiling of miRNAs in porcine germ cells during spermatogenesis. Reproduction. 2017 Dec;154(6):789-798.

(11)Chen X, Li X, Guo J, Zhang P, Zeng W*. The roles of microRNAs in regulation of mammalian spermatogenesis. J Anim Sci Biotechnol. 2017 May 1; 8: 35.