Yiyuan Niu

　　 　　

Basic information

Yiyuan Niu, born in 1990, professor and doctoral supervisor, selected for the "High Level Talent Support Program" of Northwest A&F University.

Work experience and qualifications

2023 to present, Professor, School of Animal Science and Technology, Northwest A&F University.

2022-2023, Postdoctoral fellow, BRIC Research Center, University of Copenhagen.

2018-2019, Research Assistant, BRIC Research Center, University of Copenhagen.

2019-2022, PhD, University of Copenhagen.

2014-2017, M.S in Animal Genetics, Breeding and Reproduction, Northwest A&F University.

2010-2014, B,S in bioengineering, Northwest A&F University.

Research

Mainly based on the gene editing technology mediated by the CRISPR/Cas9 system, the previous study has been conducted on the development of functional research methods for gene mutations, and the molecular breeding of sheep. A series of innovative achievements have been achieved, including: (1) The development of a functional analysis method, CRISPR-Select, for single base mutations validation, which could give an option for precise analysis of single base mutations with multi-parameters; (2) Preparation of multi-gene knockout goats and sheep, as well as single base mutant goats.

Aimed for:

（1） Efficient identification of genetic mutations related to economic traits in livestock.

（2） Molecular breeding of sheep, creating new breeding materials.

Publications

1.Niu Y, Ferreira Azevedo CA, Li X, Kamali E, Haagen Nielsen O, Storgaard Sørensen C, Frödin M. Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select. Nature Genetics. 2022 Dec;54(12):1983-93.

2.Niu Y, Zhao X, Zhou J, Li Y, Huang Y, Cai B, Liu Y, Ding Q, Zhou S, Zhao J, Zhou G. Efficient generation of goats with defined point mutation (I397V) in GDF9 through CRISPR/Cas9. Reproduction, Fertility and Development. 2018 Jan 30;30(2):307-12.

3.Niu Y, Jin M, Li Y, Li P, Zhou J, Wang X, Petersen B, Huang X, Kou Q, Chen Y. Biallelic β‐carotene oxygenase 2 knockout results in yellow fat in sheep via CRISPR/Cas9. Animal genetics. 2017 Apr;48(2):242-4.

4.Wang X, Niu Y, Zhou J, Zhu H, Ma B, Yu H, Yan H, Hua J, Huang X, Qu L, Chen Y. CRISPR/Cas9‐mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass. Animal genetics. 2018 Feb;49(1):43-51.

5.Wang X, Niu Y, Zhou J, Yu H, Kou Q, Lei A, Zhao X, Yan H, Cai B, Shen Q, Zhou S. Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep. Scientific Reports. 2016 Aug 26;6(1):32271.

Email:: yiyuan.niu@nwafu.edu.cn